Phenyl chloroformate → Phenyl N-(2-methylquinolin-3-yl)carbamate

HRID 377892ノート

反応式

HRID 377892 の反応式
[NH2:1][C:2]1[C:3]([CH3:12])=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.Cl[C:14]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:15]>C(Cl)Cl>[CH3:12][C:3]1[C:2]([NH:1][C:14](=[O:15])[O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

参加物

4

反応物 2

HCID 15891Phenyl chloroformateHCID 123006962-Methylquinolin-3-amine

生成物 1

HCID 19356949Phenyl N-(2-methylquinolin-3-yl)carbamate収率 88%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-amino-2-methylquinoline(4 g, 25 mmol) and phenyl chloroformate(4.04 g, 25 mmol) were dissolved in methylene chloride and then was stirred at room temperature for 2 hrs. The mixture solution was concentrated under the reduced pressure to remove methylene chloride and purified by column chromatography(ethylacetate:hexane=1:10) to obtain the titled compound.

後処理

  1. concentrationThe mixture solution was concentrated under the reduced pressure
  2. customto remove methylene chloride
  3. custompurified by column chromatography(ethylacetate:hexane=1:10)

出典と根拠

ORDレコード
ord-4d32dbc01ca24c418803381dafd2e4c0
出典データセット
uspto-grants-2000_02
特許番号
US06028195

反応ノート

読み込み中…