化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 1-Methoxy-4,5-dimethyl-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 3,4-Dimethylanisole | HCID 78411 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Methoxy-4,5-dimethyl-2-nitrobenzene | HCID 19357165 | 55% |
反応手順
Trifluoroacetic acid(250 ml) was added into 3,4-dimethylanisole(17.1 g, 0.13 mol), successively sodium nitrite(16.6 g, 0.24 mol) was added slowly in water bath, and stirred at room temperature for 14 hrs. After trifluoroacetic acid was removed and water was added thereto, the resulting mixture was extracted with ether, and purified by column chromatography to obtain the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028195 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-65c7820380f148e6823b876dab1e3971 |
| 出典メモ | uspto-grants-2000_02 |