反应详情

Trifluoroacetic acid(250 ml) was added into 3,4-dimethylanisole(17.1 g, 0.13 mol), successively sodium nitrite(16.6 g, 0.24 mol) was added slowly in water bath, and stirred at room temperature for 14 hrs. After trifluoroacetic acid was removed and water was added thereto, the resulting mixture was extracted with ether, and purified by column chromatography to obtain the titled compound.

1. customAfter trifluoroacetic acid was removed
2. additionwater was added
3. extractionthe resulting mixture was extracted with ether
4. custompurified by column chromatography