Dichloromethane → Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate

HRID 377917ノート

反応式

HRID 377917 の反応式
[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH2:6])=[C:4]([O:10][CH3:11])[CH:3]=1.C(Cl)Cl.Cl[C:16]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17]>O>[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH:6][C:16](=[O:17])[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:4]([O:10][CH3:11])[CH:3]=1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 15891Phenyl chloroformateHCID 193571402-Methoxy-4,5-dimethylaniline

生成物 1

HCID 19357180Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate収率 98%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 4,5-dimethyl-2-methoxyaniline(4.50 g, 0.03 mol), methylene chloride(100 ml) was added and phenyl chloroformate(4.80 g, 0.03 mol) was added slowly. The resulting solution was stirred for 2 hrs and thereto water(150 ml) was added, and extracted with methylene chloride and purified by column chromatography to obtain the titled compound.

後処理

  1. extractionextracted with methylene chloride
  2. custompurified by column chromatography

出典と根拠

ORDレコード
ord-9aaedd679882450eacbdbdc42be67a34
出典データセット
uspto-grants-2000_02
特許番号
US06028195

反応ノート

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