化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Glycine, N-(3-nitrobenzoyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Glycine | HCID 750 | — |
| 反応物 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Glycine, N-(3-nitrobenzoyl)- | HCID 94858 | 82.8% |
反応手順
A solution of glycine (200 g) and KOH (200 g) in water (1000 ml) at 0° C. was treated dropwise with a solution of m-nitrobenzoyl chloride (100 g) in acetonitrile (100 ml). The reaction was allowed to warm to room temperature and was stirred for 4 hours. 12N aqueous HCl was added until pH<2. The reaction was allowed to stand overnight at room temperature. The resulting solid was filtered and washed with water (2×250 ml) and dried in vacuo at 60° C. 100 g of m-nitrohippuric acid was isolated. MS, 1H-NMR and CHN analysis were consistent with the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028223 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-41d8df0f332f499b89e651a9a30af4f3 |
| 出典メモ | uspto-grants-2000_02 |