Hydrochloric Acid → 3,5-Dibromobenzaldehyde

HRID 378163ノート

反応式

HRID 378163 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:10])[CH:9]=1)[CH2:5]Br.C1N2CN3CN(C2)CN1C3.Cl.[OH2:22]>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:10])[CH:9]=1)[CH:5]=[O:22]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962Water2 回HCID 4101HexamethylenetetramineHCID 1434273,5-Dibromobenzyl bromide

生成物 1

HCID 6220773,5-Dibromobenzaldehyde

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To 3,5-dibromobenzylbromide (Lancaster) (20 g, 0.061 mole) in H2O (27 mL) and glacial acetic acid (27 mL) was added hexamethylenetetramine (Aldrich). The reaction mixture was heated at reflux for 2 hours. Concentrated HCl (22 mL) was then added and the refluxing was continued for 30 minutes. After cooling to room temperature, the reaction mixture was poured into H2O (230 mL) and stirred for 10 minutes. The resulting precipitate was filtered, washed with H2O and dried to yield 3,5-dibromobenzaldehyde (11.45 g) as a white solid. MS and NMR were consistent with the desired structure.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 hours
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with H2O
  5. customdried

出典と根拠

ORDレコード
ord-f3c898486bb044c3a3b6b92432ed6315
出典データセット
uspto-grants-2000_02
特許番号
US06028223

反応ノート

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