2-Methylpyridine → 2-Methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide
反応式
[Br:1][CH2:2][C:3]([CH:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4].[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17]>CO>[Br-:1].[CH3:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][N+:11]=1[CH2:2][C:3](=[O:4])[CH:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1参加物
4
実験手順
A mixture of 2-bromo-1-(tetrahydro-pyran-4-yl)-ethanone (0.6 g, 2.89 mmol) and 2-picoline (0.4 mL, 4.3 mmol) in methanol (10 mL) was heated to reflux and maintained overnight. The solvent was removed in vacuo to give a residue which was washed with 20% ethyl acetate in hexane to afford 2-methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide (0.75 g, 86%) as a semi-solid.
後処理
- temperaturewas heated
- temperatureto reflux
- temperaturemaintained overnight
- customThe solvent was removed in vacuo
- customto give a residue which
- washwas washed with 20% ethyl acetate in hexane
出典と根拠
- ORDレコード
- ord-203bea987b4746448a898a969cf61fa0
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524705B2
反応ノート
読み込み中…