Triethylamine → HCID 54144134、化合物

HRID 378289ノート

反応式

HRID 378289 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:20]=[C:19](Cl)[N:18]=[C:17]([NH:22]C)[N:16]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.CN.C([N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])C>C(O)C>[CH2:19]([NH:18][C:17]1[N:16]=[C:15]([NH:14][S:11]([C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])=[CH:10][CH:9]=2)(=[O:13])=[O:12])[CH:33]=[C:32]([NH:29][CH2:30][CH3:31])[N:22]=1)[CH3:20]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 6364545Methylamine hydrochlorideHCID 193535354-tert-butyl-N-(6-chloro-2-methylamino-pyrimidin-4-yl)-benzenesulfonamide

生成物 1

HCID 54144134HCID 54144134、化合物収率 33%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
140 °C

実験手順

0.47 g (0.0013 mol) of 4-tert-butyl-N-(6-chloro-2-methylamino-pyrimidin-4-yl)-benzenesulfonamide was dissolved in 10 ml of ethanol, treated with 1.3 g (0.019 mol) of methylamine hydrochloride and 4.7 ml (0.034 mol) of triethylamine and stirred in an autoclave at 140° C. for 18 hours. The mixture was freed completely from solvent, the residue was partitioned in ethyl acetate/water and the insoluble constituents were filtered off under suction. The filtered cake was recrystallized in methanol/diethyl ether. There was obtained 0.15 g (33%) of N-(2,6-bis-ethylamino-pyrimidin-4-yl)-4-tert-butyl-benzenesulfonamide as white crystals; m.p. 316-318° C.

後処理

  1. customthe residue was partitioned in ethyl acetate/water
  2. filtrationthe insoluble constituents were filtered off under suction
  3. customThe filtered cake was recrystallized in methanol/diethyl ether

出典と根拠

ORDレコード
ord-25dbf5c5fcb94b0c841e36448810555d
出典データセット
uspto-grants-2000_02
特許番号
US06030976

反応ノート

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