Hydrochloric Acid → 2-{[(Tert-butoxy)carbonyl](cyclopropyl)amino}acetic acid
反応式
C([O:3][C:4](=[O:10])[CH2:5][NH:6][CH:7]1[CH2:9][CH2:8]1)C.BrC[C:13]([O:15]CC)=[O:14].[CH:18]1(N)[CH2:20][CH2:19]1.Cl.[CH3:23]O>>[C:13]([N:6]([CH:7]1[CH2:8][CH2:9]1)[CH2:5][C:4]([OH:3])=[O:10])([O:15][C:20]([CH3:18])([CH3:19])[CH3:23])=[O:14]参加物
6
実験手順
Boc-N-Cyclopropylglycine was prepared from N-cyclopropylglycine ethyl ester, ethyl bromoacetate and cyclopropylamine (similar to J. W. Skiles et al., J. Med. Chem. 35 (1992) 641) and then converted under standard conditions into the Boc-protected form, then hydrolyzed with MeOH/2N NaOH and finally acidified with 1N HCl.
出典と根拠
- ORDレコード
- ord-8a5851f595b142bb9c5a1aa169a40697
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06030972
反応ノート
読み込み中…