HCID 12073752、化合物 → HCID 10432263、化合物
反応式
[CH3:1][O:2][C:3]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:4]([O:15][C:16]1[N:21]=[C:20]([O:22][CH3:23])[C:19]2[CH2:24][CH2:25][CH2:26][C:18]=2[N:17]=1)[C:5]([O:7]CC1C=CC=CC=1)=[O:6].[H][H]>C(OCC)(=O)C.CO.[Pd]>[CH3:1][O:2][C:3]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH:4]([O:15][C:16]1[N:21]=[C:20]([O:22][CH3:23])[C:19]2[CH2:24][CH2:25][CH2:26][C:18]=2[N:17]=1)[C:5]([OH:7])=[O:6]参加物
5
実験手順
40 g (78.4 mmol) of benzyl 3-methoxy-2-(4-methoxy-6,7-dihydro-5H-cyclopentapyrimidin-2-yloxy)-3,3-diphenylpropionate were dissolved in 400 ml of ethyl acetate/methanol (4:1), about 500 mg of palladium on active carbon (10%) were added, and the mixture was exposed to a hydrogen atmosphere until no further gas was taken up. The catalyst was filtered off, the solution was evaporated, and the residue was crystallized from ether.