Hydrochloric Acid → (E,E,E)-7-[1-(1-Methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl]-3-methyl-octa-2,4,6-trienoic acid

HRID 378382ノート

反応式

HRID 378382 の反応式
[CH3:1][CH:2]([N:4]1[C:13]2[C:8](=[CH:9][C:10](/[C:14](/[CH3:25])=[CH:15]/[CH:16]=[CH:17]/[C:18](/[CH3:24])=[CH:19]/[C:20]([O:22]C)=[O:21])=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH2:5]1)[CH3:3].[OH-].[Na+].Cl>C(O)C>[CH3:3][CH:2]([N:4]1[C:13]2[C:8](=[CH:9][C:10](/[C:14](/[CH3:25])=[CH:15]/[CH:16]=[CH:17]/[C:18](/[CH3:24])=[CH:19]/[C:20]([OH:22])=[O:21])=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH2:5]1)[CH3:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10569101methyl (E,E,E)-7-[1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl]-3-methylocta-2,4,6-trienoate

生成物 1

HCID 10687534(E,E,E)-7-[1-(1-Methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl]-3-methyl-octa-2,4,6-trienoic acid収率 31.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

330 mg of methyl (E,E,E)-7-[1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl]-3-methylocta-2,4,6-trienoate was dissolved in 10 ml of ethanol, followed by the addition of 1.0 ml of a 5N aqueous solution of sodium hydroxide. The obtained mixture was heated at 60° C. for one hour and adjusted to pH5 by adding 6N hydrochloric acid under cooling with ice. The crystals thus precipitated were recovered by filtration and recrystallized from ethanol to give 100 mg of the title compound as orange crystals.

後処理

  1. temperatureunder cooling with ice
  2. customThe crystals thus precipitated
  3. filtrationwere recovered by filtration
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-c9b1a470abac41cd977d66d4f6c590f2
出典データセット
uspto-grants-2000_02
特許番号
US06030964

反応ノート

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