Water → 5-(Bromomethyl)-2-chloropyridine

HRID 37855

反応式

HRID 37855 の反応式
[Br:1]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][N:29]=1.O>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:34][C:31]1[CH:32]=[CH:33][C:28]([Cl:27])=[N:29][CH:30]=1

参加物

6

反応物 4

HCID 962WaterHCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 5813932-Chloro-5-methyl-pyridine

生成物 1

HCID 64246615-(Bromomethyl)-2-chloropyridine

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

N-bromosuccinimide (6.1 g, 3.44 mmol) and benzoyl peroxide (218 mg, 0.09 mmol) were added successively to a solution of 2-chloro-5-methyl-pyridine (4.0 g, 3.13 mmol) in carbon tetrachloride (20 mL) and refluxed for 90 min. The reaction mixture was cooled to room temperature, water added and the organic layer separated. The organic layer was washed successively with water, brine, dried over anhydrous sodium sulfate and filtered. The resultant solution of 5-bromomethyl-2-chloro-pyridine was used as such for the next step.

後処理

  1. temperaturerefluxed for 90 min
  2. customthe organic layer separated
  3. washThe organic layer was washed successively with water, brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-19f91466f0b74cba80a0973a69dea6d8
出典データセット
uspto-grants-2013_09
特許番号
US08524705B2

関連ノート

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