3-Bromopropionic acid → 3-(2,5-Dimethyl-phenylsulfanyl)-propionic acid

HRID 378807ノート

反応式

HRID 378807 の反応式
[OH-].[Na+].[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[SH:11].Br[CH2:13][CH2:14][C:15]([OH:17])=[O:16]>O>[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[S:11][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 115533-Bromopropionic acidHCID 14798Sodium HydroxideHCID 776152,5-Xylenethiol

生成物 1

HCID 167883143-(2,5-Dimethyl-phenylsulfanyl)-propionic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
10 °C

実験手順

90 g (2.25 mol) of sodium hydroxide were dissolved in 500 ml of water and, with cooling at 10° C., admixed with 147.59 g of 2,5-dimethylthiophenol. Cooling was continued and 180.1 g (1.18 mol) of 3-bromopropionic acid were added below 25° C. The mixture was stirred for another 4 h at room temperature and then washed with diethyl ether (3×500 ml). The aqueous solution was made acidic using 1M HCl, and the precipitated product was filtered off and washed with water.

後処理

  1. temperatureCooling
  2. washwashed with diethyl ether (3×500 ml)
  3. filtrationthe precipitated product was filtered off
  4. washwashed with water

出典と根拠

ORDレコード
ord-a6381f356a23444b9c61ffa6e2b89451
出典データセット
uspto-grants-2001_10
特許番号
US06297196B1

反応ノート

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