Dimethylformamide diethylacetal → Ethyl 2-(6-chloropyridin-3-yl)-3-(dimethylamino)acrylate
反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.C(O[CH:17](OCC)[N:18]([CH3:20])[CH3:19])C>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[CH:17][N:18]([CH3:20])[CH3:19])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
3.99 g (20.0 mmol) of the compound from Example 1A are dissolved in 13.7 ml of dimethylformamide diethyl acetal, and the mixture is stirred with microwave irradiation at 90° C. for 30 min. The mixture is then concentrated on a rotary evaporator, and the residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1).
後処理
- concentrationThe mixture is then concentrated on a rotary evaporator
- customthe residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1)
出典と根拠
- ORDレコード
- ord-16cc391b4b8f4a33be01b15eb6e4129f
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524699B2
反応ノート
読み込み中…