Oxalyl chloride → 4-Bromo-2-methylbenzoyl chloride

HRID 378894ノート

反応式

HRID 378894 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[CH:3]=1.C(Cl)(=O)C([Cl:15])=O>ClCCl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([CH3:11])[CH:3]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 995704-Bromo-2-methylbenzoic acid

生成物 1

HCID 128464834-Bromo-2-methylbenzoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane触媒

実験手順

A suspension of 4bromo-2-methylbenzoic acid (4.9 g, 22.8 mmol) in dichioromethane containing a few drops of N,N-dimethylformamde was treated dropwise under nitrogen with oxalyl chloride (2.4 mL, 27.5 mol). After gas evolution subsided, the reaction mixture was refluxed for an additional 15 minutes and then evaporated to dryness in vacuo to provide the crude 4-bromo-2-methylbenzoyl chloride.

後処理

  1. temperaturethe reaction mixture was refluxed for an additional 15 minutes
  2. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-b5ef46d355a645e1ae379e14e4216879
出典データセット
uspto-grants-2001_10
特許番号
US06297234B1

反応ノート

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