Formaldehyde → 3-(4-Methoxyphenyl)-5,6-dihydroimidazo[1,5-c]quinazoline

HRID 378901

反応式

HRID 378901 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH2:20])[N:13]=2)=[CH:5][CH:4]=1.[CH2:21]=O>C(O)(=O)C.C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:13]3[CH2:21][NH:20][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[C:12]3=[CH:11][N:10]=2)=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 712FormaldehydeHCID 178488922HCID 178488922、化合物

生成物 1

HCID 154787163-(4-Methoxyphenyl)-5,6-dihydroimidazo[1,5-c]quinazoline

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-(4-Methoxyphenyl)-4-(2-aminophenyl)imidazole (5 g) is dissolved in acetic acid (20 ml) and formaldehyde (37% in water, 1.53 ml) is added. The reaction is stirred for 2 min., diluted with ethyl acetate (100 ml), and extracted with 5%HCl (250 ml). The aqueous layer is basified with K2CO3, then extracted with ethyl acetate. The organic layer is evaporated under reduced pressure and the residue is recrystallized from dichloromethane to afford 3-(4-methoxyphenyl)-5,6-dihydroimidazo[1,5-c]quinazoline (3 g) as a light brown solid. m.p. 190-191° C.

後処理

  1. extractionextracted with 5%HCl (250 ml)
  2. extractionextracted with ethyl acetate
  3. customThe organic layer is evaporated under reduced pressure
  4. customthe residue is recrystallized from dichloromethane

出典と根拠

ORDレコード
ord-2057ce4073d3435eb24c3fa45fe7efb8
出典データセット
uspto-grants-2001_10
特許番号
US06297252B1

関連ノート

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