Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine

HRID 37891

反応式

HRID 37891 の反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:7]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 709434,6-Dichloropyrimidine

生成物 1

HCID 7960704-(6-Chloropyrimidin-4-yl)morpholine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

45.0 g (302.1 mmol) of 4,6-dichloropyrimidine are initially charged in 450 ml of water. 26.3 g (302.1 mmol) of morpholine are added, and the mixture is stirred at 90° C. for 16 h. The mixture is then cooled to 0° C., and the precipitate formed is filtered off. The precipitate is washed once with 50 ml of water and air-dried.

後処理

  1. temperatureThe mixture is then cooled to 0° C.
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washThe precipitate is washed once with 50 ml of water
  5. customair-dried

出典と根拠

ORDレコード
ord-d1f9ab0e57eb42c6b0e421bc0e8cbff6
出典データセット
uspto-grants-2013_09
特許番号
US08524699B2

関連ノート

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