3-Aminoazetidine, 3-BOC protected → tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate

HRID 37911

反応式

HRID 37911 の反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[C:12](=[O:13])[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)=[CH:10][NH:9]2)[CH:3]=1.[NH:20]1[CH2:23][CH:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:21]1>C(O)C>[O:13]=[C:12]1[N:8]([C:4]2[N:5]=[CH:6][N:7]=[C:2]([N:20]3[CH2:23][CH:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:29])([CH3:28])[CH3:30])[CH2:21]3)[CH:3]=2)[NH:9][CH:10]=[C:11]1[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1

参加物

4

反応物 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 866723282-(6-Chloropyrimidin-4-yl)-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one

生成物 1

HCID 70302327tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

200 mg (0.7 mmol) of the compound from Example 23 and 252 mg (1.5 mmol) of tert-butyl azetidin-3-ylcarbamate are suspended in 6 ml of ethanol and reacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min. The solid formed is filtered off, washed twice with in each case 0.5 ml of ethanol and dried under high vacuum.

後処理

  1. customreacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed twice with in each case 0.5 ml of ethanol
  5. customdried under high vacuum

出典と根拠

ORDレコード
ord-61ffad6f04f34b6db1d26cca5588c567
出典データセット
uspto-grants-2013_09
特許番号
US08524699B2

関連ノート

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