3-Chloroaniline → Methanimidamide, N'-(3-chlorophenyl)-N,N-dimethyl-

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH:14]=[N:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=1)[CH3:13]

参加物

反応物 2

HCID 79323-Chloroaniline

HCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 415383Methanimidamide, N'-(3-chlorophenyl)-N,N-dimethyl-収率 100.5%

実験手順

A mixture of 3-chloroaniline (63.8 g, 0.50 mol) and dimethylformamide dimethyl acetal (106 ml, 0.75 mol) was heated at 100° for 2 h and evaporated at 60° at 0.5 mm Hg to give 91.8 g amber oil; ms 183.0 (M+H)+.

後処理

temperaturewas heated at 100° for 2 h
customevaporated at 60° at 0.5 mm Hg

出典と根拠

ORDレコード: ord-a43756d4150345288e47068a29a390c2
出典データセット: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06297258B1

反応ノート

読み込み中…

参加物