7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine → 5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde

HRID 379229ノート

反応式

HRID 379229 の反応式
C[O:2][CH:3](OC)[C:4]1[CH:13]=[CH:12][C:11]2[CH2:10][CH2:9][CH2:8][NH:7][C:6]=2[N:5]=1>FC(F)(F)C(O)=O>[N:5]1[C:6]2[NH:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=[CH:13][C:4]=1[CH:3]=[O:2]

参加物

3

反応物 1

HCID 177501767-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

生成物 1

HCID 218737255,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

8-2 (10 g, 0.048 mol) was treated with trifluoroacetic acid (50 mL) and the resulting solution stirred under argon for 12.5 h. The TFA was removed at reduced pressure and the residue partitioned between sat. NaHCO3 and CH2Cl2. The organic layer was dried, concentrated and passed through a 3 in. pad of silica gel (10% acetone/CH2Cl2) and concentrated to afford 8-3 as a yellow crystalline solid.

後処理

  1. customThe TFA was removed at reduced pressure
  2. customthe residue partitioned between sat. NaHCO3 and CH2Cl2
  3. customThe organic layer was dried
  4. concentrationconcentrated
  5. concentrationpad of silica gel (10% acetone/CH2Cl2) and concentrated

出典と根拠

ORDレコード
ord-81333ece685042648560ab860a57270d
出典データセット
uspto-grants-2001_10
特許番号
US06297249B1

反応ノート

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