Sodium Azide → 3-Azido-indan-1-one

HRID 379335

反応式

HRID 379335 の反応式
Br[CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3]1.[N-:12]=[N+:13]=[N-:14].[Na+]>CN(C=O)C>[N:12]([CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3]1)=[N+:13]=[N-:14]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 117459123-Bromo-1-indanone

生成物 1

HCID 216985633-Azido-indan-1-one収率 86%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirring solution of 3-Bromo indan-1-one (400 mg, 1.90 mmol) in DMF (5 ml) was added sodium azide (1.98 g, 0.03 mol). The reaction was allowed to stir at room temperature for 15 mins. The product was partitioned between water (10 ml) and ether (10 ml). The ether layers were combined and the crude reaction mixture was passed through a plug of flash silica, eluting with petroleum ether:ethyl acetate (9:1). The product was isolated as an orange oil (283 mg, 86%).

後処理

  1. customThe product was partitioned between water (10 ml) and ether (10 ml)
  2. customthe crude reaction mixture
  3. washeluting with petroleum ether:ethyl acetate (9:1)

出典と根拠

ORDレコード
ord-eed564b2fbf242f284c2735251596e23
出典データセット
uspto-grants-2001_10
特許番号
US06297399B1

関連ノート

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