Trifluoroacetic acid → HCID 18366628、化合物
反応式
O[CH:2]([C:23]1[N:27]([CH3:28])[C:26]2[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=2[N:24]=1)[C:3]1[S:18][C:6]2[N:7]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:8](=[O:13])[N:9]([CH3:12])[C:10](=[O:11])[C:5]=2[C:4]=1[S:19][CH:20]([CH3:22])[CH3:21].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[CH3:12][N:9]1[C:10](=[O:11])[C:5]2[C:4]([S:19][CH:20]([CH3:21])[CH3:22])=[C:3]([CH2:2][C:23]3[N:27]([CH3:28])[C:26]4[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=4[N:24]=3)[S:18][C:6]=2[N:7]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:8]1=[O:13]参加物
4
実験手順
Prepared according to the method described in Example 39 from 6-[hydroxy(1-methyl-1H-benzimidazol-2-yl)methyl]-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.48 g, Example 44), trifluoroacetic acid (6 ml) and triethylsilane (3 ml) with stirring at room temperature for 24 hours. After work up, the residue was absorbed onto silica and purified by flash silica chromatography eluting with acetone:isohexane (1:5) to give the title compound as a white foam (0.135 g).