Diethyl[2-(4-nitrophenoxy)ethyl]amine → 4-(2-(Diethylamino)ethoxy)aniline

HRID 379699

反応式

HRID 379699 の反応式
[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]>[C].[Pd].CO>[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]

参加物

4

反応物 1

HCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

生成物 1

HCID 4189324-(2-(Diethylamino)ethoxy)aniline収率 98.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

N,N-diethyl-2-(4-nitrophenoxy)ethylamine (28.19 g) was dissolved into methanol (300 ml) and subjected to hydration reaction at ambient pressure by adding 10% palladium carbon catalyst (1.5 g). After completion of hydration reaction, catalyst was removed by filtration. Filtrate was concentrated under vacuum to obtain N,N-diethyl-2-(4-aminophenoxy)ethylamine (24.25 g) as color-less oily substance.

後処理

  1. customsubjected to hydration reaction at ambient pressure
  2. customAfter completion of hydration reaction, catalyst
  3. customwas removed by filtration
  4. concentrationFiltrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-72a8bec4006c486aac01b693cc55603e
出典データセット
uspto-grants-2001_10
特許番号
US06300368B1

関連ノート

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