Bromomethyl 3-methoxyphenyl ketone → 3-Amino-6-chloro-1-ethoxycarbonyl-2-(3-methoxybenzoyl)indole

HRID 379727

反応式

HRID 379727 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)=[O:19]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18](=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1

参加物

3

反応物 2

HCID 101294Bromomethyl 3-methoxyphenyl ketoneHCID 183678884-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile

生成物 1

HCID 183677433-Amino-6-chloro-1-ethoxycarbonyl-2-(3-methoxybenzoyl)indole

実験手順

The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromo-3′-methoxyacetophenone. 1H-NMR (CDCl3) δ: 8.25 (1H, d, J=1.5 Hz), 7.53 (1H, d, J=8.4 Hz), 7.36-7.26 (4H, m), 7.05-7.01 (1H, m), 5.78 (2H, s), 3.84 (3H, s), 3.78 (2H, q, J=7.0 Hz), 0.89 (3H, t, J=7.0 Hz).

出典と根拠

ORDレコード
ord-d24454c6e5304e5f9b22cf3e4a6e9acb
出典データセット
uspto-grants-2001_10
特許番号
US06300363B1

関連ノート

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