Aluminium lithium hydride → (2s)-2-(Biphenyl-4-yloxy)propan-1-ol
反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:12]=[CH:11][C:10]([O:13][C@@H:14]([CH3:20])[C:15](OCC)=[O:16])=[CH:9][CH:8]=1>O1CCCC1>[C:7]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:8]=[CH:9][C:10]([O:13][C@@H:14]([CH3:20])[CH2:15][OH:16])=[CH:11][CH:12]=1参加物
4
実験手順
Prepared according to the method described in Example 1b) from lithium aluminium hydride (41.9 ml, 1.0M solution in ether) and solution (2S)-2-(biphenyl-4-yloxy)propanoic acid, ethyl ester (11.3 g, Example 2a)) in dry tetrahydrofuran (200 ml) at 0° C. The sub-title compound obtained after work-up was used directly without further purification (9.52 g).
後処理
- customPrepared
- customat 0° C
出典と根拠
- ORDレコード
- ord-305a614b541143e2abd114761b04c157
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06300352B1
反応ノート
読み込み中…