Water → 4-Bromo-2,5-difluorobenzenesulfonamide

HRID 380000

反応式

HRID 380000 の反応式
[OH-].[NH4+:2].[F:3][C:4]1[CH:9]=[C:8]([Br:10])[C:7]([F:11])=[CH:6][C:5]=1[S:12](Cl)(=[O:14])=[O:13].O>O1CCCC1>[Br:10][C:8]1[C:7]([F:11])=[CH:6][C:5]([S:12]([NH2:2])(=[O:14])=[O:13])=[C:4]([F:3])[CH:9]=1

参加物

5

反応物 3

HCID 962WaterHCID 14923Ammonium HydroxideHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

生成物 1

HCID 27732934-Bromo-2,5-difluorobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ammonium hydroxide (5 ml) was added to a solution of 2,5-difluoro-4-bromophenylsulfonyl chloride (4.3 g) in tetrahydrofuran (20 ml) at room temperature (CARE:exotherm) and stirred for 10 min. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated and the residue triturated with 20% diethyl ether in isohexane to give the sub-title compound as a solid (4.3 g).

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customThe filtrate was evaporated
  5. customthe residue triturated with 20% diethyl ether in isohexane

出典と根拠

ORDレコード
ord-80781d6e4daf441a96141ea53578b925
出典データセット
uspto-grants-2001_10
特許番号
US06300352B1

関連ノート

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