tert-Butanol → ClCF2-CH2-O-CF2CFHBr

HRID 380085

反応式

HRID 380085 の反応式
[Cl:1][C:2]([CH2:5][OH:6])([F:4])[F:3].C(O)(C)(C)C.[OH-].[K+].[C:14](=[C:17]([Br:19])[F:18])([F:16])[F:15]>O>[Cl:1][C:2]([CH2:5][O:6][C:14]([CH:17]([Br:19])[F:18])([F:16])[F:15])([F:4])[F:3].[C:2](=[CH:5][O:6][C:14]([CH:17]([Br:19])[F:18])([F:16])[F:15])([F:4])[F:3]

参加物

7

反応物 4

HCID 6386tert-ButanolHCID 117301-Bromo-1,2,2-trifluoroetheneHCID 14797Potassium HydroxideHCID 38641482-Chloro-2,2-difluoroethan-1-ol

生成物 2

HCID 21696368ClCF2-CH2-O-CF2CFHBr収率 89%HCID 88022705HCID 88022705、化合物収率 11%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 50 ml glass reactor equipped with PTFE valve and magnetic stirring, 2.4 g (0.02 moles) of ClCF2—CH2—OH, 5 ml of tert-butyl alcohol, 1.1 g (0.02 moli) of KOH and 3.5 g of CF2═CFBr (0.022 moles) are fed. The reaction mixture is left under stirring at room temperature for three hours. The organic phase is then diluted with water, separated, washed twice with slightly acid water by HCl and anhydrified. 5 g of a mixture having the following composition: 89% ClCF2—CH2—O—CF2CFHBr and 11% CF2═CH—O—CF2CFHBr are obtained.

後処理

  1. customIn a 50 ml glass reactor equipped with PTFE valve
  2. waitThe reaction mixture is left
  3. customseparated
  4. washwashed twice with slightly acid water by HCl

出典と根拠

ORDレコード
ord-1dc9998e4b1d4138a80acbdb9350282f
出典データセット
uspto-grants-2001_10
特許番号
US06300526B1

関連ノート

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