(1s,4r)-4-Propylcyclohexane-1-carboxylic acid → HCID 18364509、化合物

HRID 380258

反応式

HRID 380258 の反応式
[C:1]([C:3]1([OH:18])[CH2:8][CH2:7][CH:6]([CH:9]2[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][CH3:17])[CH2:11][CH2:10]2)[CH2:5][CH2:4]1)#[CH:2].[CH2:19]([CH:22]1[CH2:27][CH2:26][CH:25]([C:28](O)=[O:29])[CH2:24][CH2:23]1)[CH2:20][CH3:21]>CN(C)C1C=CN=CC=1.ClCCl>[CH2:19]([CH:22]1[CH2:27][CH2:26][CH:25]([C:28]([O:18][C:3]2([C:1]#[CH:2])[CH2:8][CH2:7][CH:6]([CH:9]3[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][CH3:17])[CH2:11][CH2:10]3)[CH2:5][CH2:4]2)=[O:29])[CH2:24][CH2:23]1)[CH2:20][CH3:21]

参加物

5

反応物 2

HCID 1490324(1s,4r)-4-Propylcyclohexane-1-carboxylic acidHCID 18364504HCID 18364504、化合物

生成物 1

HCID 18364509HCID 18364509、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒2 回

実験手順

4.00 g of 4-(dimethylamino)pyridine are added to a solution of 16.00 g of 4-ethynyl-4′-propylbicyclohexyl-4-ol and 11.51 g of 4-propylcyclohexanecarboxylic acid in 120 ml of dichloromethane. 9.66 g of N,N-dicyclohexylcarbodiimide in 30 ml of methylene chloride are subsequently added dropwise at RT, and the mixture is stirred overnight. Conventional work-up gives 4-ethynyl-4′-propylbicyclohexyl-4-yl 4-propylcyclohexane-carboxylate (C 59 N 120 I, Δε−1.57, Δn 0.04).

出典と根拠

ORDレコード
ord-a96f2bb302f6403a9cceb95ee0e5273e
出典データセット
uspto-grants-2001_10
特許番号
US06303194B1

関連ノート

読み込み中…