Thionyl Chloride → 5-Methylfuran-2-carbonyl chloride

HRID 380332

反応式

HRID 380332 の反応式
O=S(Cl)[Cl:3].[CH3:5][C:6]1[O:10][C:9]([C:11]([OH:13])=O)=[CH:8][CH:7]=1>C1C=CC=CC=1>[CH3:5][C:6]1[O:10][C:9]([C:11]([Cl:3])=[O:13])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 747102-Furancarboxylic acid, 5-methyl-

生成物 1

HCID 27598515-Methylfuran-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
80 °C

実験手順

A solution of 0.31 g of SOCl2 in 2 ml of benzene was added dropwise at 0° C. under nitrogen atmosphere to a solution of 0.22 g of 5-methylfuran-2-carboxylic acid, prepared following the method described by Robert et al., Eur. J. Med. Chem. 30, 915-924 (1995), in 5 ml of benzene. The mixture was stirred at 80° C. for 1 hour and the excess SOCl2 was then distilled off. The residue (0.24 g, 97% of theory) was utilized for the next step without further purification.

後処理

  1. customprepared
  2. distillationthe excess SOCl2 was then distilled off
  3. customThe residue (0.24 g, 97% of theory) was utilized for the next step without further purification

出典と根拠

ORDレコード
ord-da1d7a3331eb4f55bbba98c35de86592
出典データセット
uspto-grants-2001_10
特許番号
US06303606B1

関連ノート

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