関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| 反応物 | 2,4-Dichloropyrimidine-5-carbonyl chloride | HCID 13784112 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,4-Dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide | HCID 86664758 | 60% |
反応手順
2,4-Dichloropyrimidine-5-carbonyl chloride (1 g, 5 mmol) was dissolved in CH2Cl2 (20 mL), 2,2,2-trifluoroethylamine (515 mg, 5 mmol) and triethylamine (1.31 mL, 9 mmol) were added. The reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was purified by flash chromatography to yield a white solid (780 mg, 60%). MS: m/z=271.9 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524710B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-e3e74a819e39477187627512570c9e67 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
