Formic Acid → 1-methyl-1H-indole-7-carboxylic acid

HRID 380471ノート

反応式

HRID 380471 の反応式
C([O:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:19]=1[N:18]([CH3:20])[CH:17]=[CH:16]2)=[O:10])C1C=CC=CC=1.C(O)=O>CO.[Pd]>[CH3:20][N:18]1[C:19]2[C:15](=[CH:14][CH:13]=[CH:12][C:11]=2[C:9]([OH:10])=[O:8])[CH:16]=[CH:17]1

参加物

5

反応物 2

HCID 284Formic AcidHCID 18388396Benzyl-1-methylindole-7-carboxylate

生成物 1

HCID 183883621-methyl-1H-indole-7-carboxylic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 0.65 g (0.25 mmol) of benzyl-1-methylindole-7-carboxylate (Step B) and 0.035 g of 10% Pd/C in 4 mL of a solution of 4.4% HCO2H in MeOH was stirred for 2 h at rt. The reaction mixture was filtered though a thin pad of celite and concentrated to give the title compound. 1H NMR (CDCl3) δ4.00 (s, 3H), 6.61 (d, 1H, J=3 Hz), 7.11 (d, 1H, J=3 Hz), 7.18 (t, 1H, J=8 Hz), 7.87 (d, 1H, J=8 Hz), 7.91 (d, 1H, J=8 Hz);

後処理

  1. filtrationThe reaction mixture was filtered though a thin pad of celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-7fd79f8e079043328b13b6fa665101de
出典データセット
uspto-grants-2001_10
特許番号
US06303593B1

反応ノート

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