1-Benzyl-4-(3-phenylpropyl)piperidin-4-ol → 4-(3-Phenylpropyl)piperidin-4-ol
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([OH:23])([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[OH:23][C:11]1([CH2:14][CH2:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1参加物
4
実験手順
A mixture of 3.3 g (10.7 mmol) of 1-benzyl-4-hydroxy-4-(3-phenylpropyl)piperidine and 0.5 g of Pd(OH)2 (Pearlman's catalyst) in 80 mL of MeOH was hydrogenated at 50 psi for 24 h. The reaction mixture was filtered through a thin pad of celite and concentrated to give the title compound.
後処理
- filtrationThe reaction mixture was filtered through a thin pad of celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-40a77371a6cb480f8c0eb67477e659d4
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06303593B1
反応ノート
読み込み中…