HCID 9801910、化合物 → HCID 9927277、化合物

HRID 380573ノート

反応式

HRID 380573 の反応式
C([N:8]1[CH2:13][CH2:12][C:11]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([CH2:14][NH:15][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])=[O:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[OH-].[OH-].[Pd+2].C(O)(=O)C.CO>[C:26]1([C:11]2([CH2:14][NH:15][C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])=[O:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

参加物

6

反応物 2

HCID 9801910HCID 9801910、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 9927277HCID 9927277、化合物

試薬・触媒・溶媒 3

HCID 176Acetic Acid触媒HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A mixture of 1.3 g (3.1 mmol) of 1-N-Benzyl-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)piperidine (Example 1), 100 mg of Pearlman's catalyst (palladium hydroxide on carbon, purchased from Aldrich Chemical Co., Milwaukee, Wis.) and 3 drops of acetic acid in 20 mL of methanol was stirred in a hydrogen atmosphere (50 psi) for 18 hr. The reaction mixture was filtered and the filtrate was concentrated to afford the title compound.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-d0b067c17a154133b18fef4d0d5f615a
出典データセット
uspto-grants-2001_10
特許番号
US06303637B1

反応ノート

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