Pyridine → HCID 9799302、化合物

HRID 380574ノート

反応式

HRID 380574 の反応式
[C:1]1([C:7]2([CH2:13][NH:14][C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])=[O:16])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.[C:31](OC(=O)C)(=[O:33])[CH3:32]>C(OCC)(=O)C>[C:31]([N:10]1[CH2:9][CH2:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([CH2:13][NH:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])=[O:16])[CH2:12][CH2:11]1)(=[O:33])[CH3:32]

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 9927277HCID 9927277、化合物

生成物 1

HCID 9799302HCID 9799302、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 0.1 g (0.31 mmol) of 4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)piperidine (Example 2), 0.025 mL of pyridine (0.31 mmole) in 2 mL of acetic anhydride was mixed for 18 hr. The reaction was diluted with ethyl acetate and washed with saturated NaHCO3. The organic fraction was dried over MgSO4 and the filtrate was concentrated. The residue was purified by chromatography (silica, ethyl acetate) to give the title compound.

後処理

  1. washwashed with saturated NaHCO3
  2. dry with materialThe organic fraction was dried over MgSO4
  3. concentrationthe filtrate was concentrated
  4. customThe residue was purified by chromatography (silica, ethyl acetate)

出典と根拠

ORDレコード
ord-7f3d87702da142f4a024b6a5e269bd2f
出典データセット
uspto-grants-2001_10
特許番号
US06303637B1

反応ノート

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