Dimethyl Sulfoxide → 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine

HRID 3810

反応式

HRID 3810 の反応式
Br[CH2:2][CH2:3][CH2:4][Cl:5].[Cl:6][C:7]1[CH:21]=[CH:20][C:10]([CH2:11][N:12]2[CH2:17][CH:16]([CH3:18])[NH:15][CH2:14][CH:13]2[CH3:19])=[CH:9][CH:8]=1.[OH-].[K+].CS(C)=O>O>[Cl:6][C:7]1[CH:21]=[CH:20][C:10]([CH2:11][N:12]2[CH2:17][CH:16]([CH3:18])[N:15]([CH2:2][CH2:3][CH2:4][Cl:5])[CH2:14][CH:13]2[CH3:19])=[CH:9][CH:8]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 223135764-Chlorobenzyl-2,5-dimethylpiperazine

生成物 1

HCID 201531901-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine収率 58%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

22.0 g g of 1-bromo-3-chloropropane were added to a mixture of 33.0 g of 4-chlorobenzyl-2,5-dimethylpiperazine, 25.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide. After stirring the solution for 3 hours at room temperature, water was added, the product was extracted with ether, and the extract was dried (magnesium sulfate) and concentrated to give 25.8 g (58% of theory) of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine as an oil, suitable for use in the next reaction.

後処理

  1. extractionthe product was extracted with ether
  2. dry with materialthe extract was dried (magnesium sulfate)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-73dfc2a4ed354bdeacc95510bbfc783d
出典データセット
uspto-grants-1988_02
特許番号
US04722926

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