(4-Chloro-3-methoxyphenyl)methanol → 4-Chloro-3-methoxybenzaldehyde
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[O:10][CH3:11]>C1C=CC=CC=1.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[O:10][CH3:11]参加物
4
実験手順
To a solution of (4-chloro-3-methoxyphenyl)methan-1-ol (5.08 g, 29.4 mmol) in benzene (120 mL) was added MnO2 (5.65 g, 65 mmol). The reaction mixture was refluxed for 17 hr, chilled, and filtered through Celite, washing the cake with CH2Cl2 (300 mL). The filtrate was concentrated in vacuo to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89%).
後処理
- temperatureThe reaction mixture was refluxed for 17 hr
- temperaturechilled
- filtrationfiltered through Celite
- washwashing the cake with CH2Cl2 (300 mL)
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-f074e120e9b04d9f9e37f175fd9d00c9
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524721B2
反応ノート
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