3-Acetaminobenzyl alcohol → N-(3-formylphenyl)acetamide

HRID 38158

反応式

HRID 38158 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1>C1(C)C=CC=CC=1.O=[Mn]=O>[CH:2]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1)=[O:1]

参加物

4

反応物 1

HCID 966393-Acetaminobenzyl alcohol

生成物 1

HCID 256849N-(3-formylphenyl)acetamide収率 93%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒2 回HCID 1140Toluene溶媒

実験手順

A mixture of N-[3-(hydroxymethyl)phenyl]acetamide (10 g, 60.6 mmol) and MnO2 (7.8 g, 90 mmol) in toluene (250 mL) was refluxed for 29 hr, with addition of more MnO2 (0.7 g, 9 mmol) at 24 hr. The reaction was cooled, filtered through Celite and concentrated in vacuo to give N-(3-formylphenyl)acetamide (9.2 g, 75%). ES-MS (M+H)+=164.

後処理

  1. temperatureThe reaction was cooled
  2. filtrationfiltered through Celite
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-608dc77e9c7041d8a6b76f2f2709fde6
出典データセット
uspto-grants-2013_09
特許番号
US08524721B2

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