Trifluoroacetic acid → 3-(4-Aminophenyl)-1,3-dihydroquinazoline-2,4-dione trifluoroacetate

HRID 38164

反応式

HRID 38164 の反応式
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:24](=[O:25])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16]2=[O:26])=[CH:11][CH:10]=1)=O)(C)(C)C.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>C(Cl)Cl>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:24](=[O:25])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16]2=[O:26])=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 91580089(Tert-butoxy)-n-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide

生成物 1

HCID 220643913-(4-Aminophenyl)-1,3-dihydroquinazoline-2,4-dione trifluoroacetate収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a chilled suspension of (tert-butoxy)-N-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide (0.35 g, 1 mmol) in CH2Cl2 (2 mL) was added neat TFA (2 mL). The resulting solution was stirred cold for 1 hr, concentrated in vacuo, azeotroped with heptane and dried to give desired compound (0.376 g, 99%) as the mono TFA salt. ES-MS (M+H)+=254.

後処理

  1. concentrationconcentrated in vacuo
  2. customazeotroped with heptane
  3. customdried

出典と根拠

ORDレコード
ord-dcd4b6308e2d4d7486802c74d0e49f0d
出典データセット
uspto-grants-2013_09
特許番号
US08524721B2

関連ノート

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