Phenylpropanolamine → (1S,2R)-2-amino-1-phenylpropan-1-ol

HRID 381651

反応式

HRID 381651 の反応式
[CH3:1][C@H:2]([NH2:11])[C@H:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[BH4-].[Na+]>C(O)C>[CH3:1][C@@H:2]([NH2:11])[C@@H:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

実験手順

As shown in the scheme above, (1R, 2S)-(−)-norephedrine is reacted with an optionally substituted benzaldehyde by refluxing in ethanol, and reducing the product of that reaction with sodium borohydride at ambient temperature to produce the desired norephedrine derivative compound.

出典と根拠

ORDレコード
ord-1d749c0eef934d3cbcb4053555977afb
出典データセット
uspto-grants-2001_10
特許番号
US06307048B1

関連ノート

読み込み中…