Ethyl 2-methyl-4,4,4-trifluoroacetoacetate → Ethyl 2-methyl-3-hydroxy-4,4,4-trifluorobutyrate

HRID 381797

反応式

HRID 381797 の反応式
[CH3:1][CH:2]([C:8]([C:10]([F:13])([F:12])[F:11])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[H][H]>[Pt].C(N(CC)CC)C>[CH3:1][CH:2]([CH:8]([OH:9])[C:10]([F:13])([F:11])[F:12])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

参加物

5

反応物 2

HCID 2737204Ethyl 2-methyl-4,4,4-trifluoroacetoacetateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 533787Ethyl 2-methyl-3-hydroxy-4,4,4-trifluorobutyrate収率 96%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8471Triethylamine溶媒

反応条件

温度
40 °C

実験手順

Ethyl 2-methyl-4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.1 g of 5% Pt/C, 0.01% load) and triethylamine (0.2 g, 0.4 % load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 48.5 g (96% yield) of ethyl 2-methyl-4,4,4-trifluoro-3-hydroxybutyrate is obtained.

後処理

  1. filtrationAfter filtration
  2. customto remove the catalyst

出典と根拠

ORDレコード
ord-18e99ffb26774e509b424843c2cef869
出典データセット
uspto-grants-2001_10
特許番号
US06307094B1

関連ノート

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