Methanesulfonic Acid → Ethyl 4,4,4-trifluoro-3-hydroxybutanoate

HRID 381798

反応式

HRID 381798 の反応式
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].CS(O)(=O)=O.[H][H]>[Pt]>[F:1][C:2]([F:11])([F:12])[CH:3]([OH:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

5

反応物 3

HCID 6395Methanesulfonic AcidHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 136210Ethyl 4,4,4-trifluoro-3-hydroxybutanoate収率 50.1%

試薬・触媒・溶媒 1

HCID 23939Platinum触媒

反応条件

温度
40 °C

実験手順

Ethyl 4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.1 g of 5% Pt/C, 0.01% load) and methanesulfonic acid (1.5 g, 2.9% load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 25.3 g (50% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate is obtained.

後処理

  1. filtrationAfter filtration
  2. customto remove the catalyst

出典と根拠

ORDレコード
ord-d5a853887b8d4c2fb460537e3b147d6c
出典データセット
uspto-grants-2001_10
特許番号
US06307094B1

関連ノート

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