Water → HCID 59971430、化合物

HRID 382009

反応式

HRID 382009 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:11])[NH:6]2.[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH:17]=O.O>N1CCCCC1.CC(O)C>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1/[C:4](=[CH:17]/[C:13]1[NH:12][CH:16]=[CH:15][CH:14]=1)/[C:5](=[O:11])[NH:6]2

参加物

6

反応物 3

HCID 962WaterHCID 13854Pyrrole-2-carboxaldehydeHCID 27631904-bromo-2,3-dihydro-1H-indol-2-one

生成物 1

HCID 59971430HCID 59971430、化合物

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 8082Piperidine溶媒

反応条件

温度
85 °C

実験手順

A mixture of 4-bromo-1,3-dihydro-2H-indol-2-one (0.2 g, 0.94 mmol) (see Kosuge et al., supra), and excess pyrrole-2-carboxaldehyde (0.11 g, 1.13 mmol) (Aldrich) in 1% piperidine in 2-propanol (2 mL) was heated at 85° C. for 2 h. Hot water (2 mL) was added. On cooling, the crystallized product was filtered off, washed with aqueous 2-propanol and dried. (Yield 0.26 g, 96%).

後処理

  1. temperatureOn cooling
  2. filtrationthe crystallized product was filtered off
  3. washwashed with aqueous 2-propanol
  4. customdried

出典と根拠

ORDレコード
ord-fb8c200ef8b14006b47ac1d51ac9f564
出典データセット
uspto-grants-2001_10
特許番号
US06307056B1

関連ノート

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