Dimethylformamide dimethyl acetal → (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate

HRID 38236

反応式

HRID 38236 の反応式
[O:1]=[C:2]([CH2:9][CH3:10])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>CN(C=O)C>[CH3:13][N:14](/[CH:16]=[C:3](\[C:2](=[O:1])[CH2:9][CH3:10])/[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:15]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 78656Ethyl 3-oxovalerate

生成物 1

HCID 11820077(E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate収率 100%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

According to Scheme 9 Step 1: A solution of ethyl 3-oxopentanoate (13.9 mmol, 2.00 g) and of 1,1-dimethoxy-N,N-dimethylmethanamine (13.9 mmole, 1.84 mL) in DMF (10 mL) was microwaved for 30 min at 120° C. After evaporation of the solvent, 2.76 g (13.9 mmol) of (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate were obtained and used without further purification.

後処理

  1. customAfter evaporation of the solvent

出典と根拠

ORDレコード
ord-36ed30f54e374bdc94cf8a2fd6430b5a
出典データセット
uspto-grants-2013_09
特許番号
US08524718B2

関連ノート

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