反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:14].[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH:20]=[CH:21][C:22](Cl)=O.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.[C:53]([OH:58])(=[O:57])[C:54]([OH:56])=[O:55]>C(OCC)(=O)C>[C:53]([OH:58])(=[O:57])[C:54]([OH:56])=[O:55].[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])/[CH:20]=[CH:21]/[C:22]1[N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:14]=1参加物
6
実験手順
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and 3,4-dimethoxycinnamoyl chloride (Ramamurthy, B.; Sugumaran, M. Synthesis, 1987, 523) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
後処理
- concentrationConcentration and recrystallization from ethyl acetate/n-hexane
出典と根拠
- ORDレコード
- ord-703a92826bf54efe8e7f23d7dcd68d88
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06310079B1
関連ノート
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