2-Nitro-N-(2-pyridyl)-4-trifluoromethylaniline → 1,2-Benzenediamine, N1-2-pyridinyl-4-(trifluoromethyl)-

HRID 382551

反応式

HRID 382551 の反応式
[N+:1]([C:4]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[CH:13][C:5]=1[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:16]=[C:15]([C:17]([F:20])([F:18])[F:19])[CH:14]=[CH:13][C:5]=1[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

参加物

4

反応物 1

HCID 227366382-Nitro-N-(2-pyridyl)-4-trifluoromethylaniline

生成物 1

HCID 227367071,2-Benzenediamine, N1-2-pyridinyl-4-(trifluoromethyl)-収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 2-nitro-N-(2-pyridyl)-4-trifluoromethylaniline (1.00 g, 3.5 mmol), 5% palladium on carbon (0.23 g) and methanol (50 ml) was stirred under a hydrogen atmosphere for 100 min. The mixture was filtered through a pad of celite and the filtrate was concentrated to dryness to give 0.75 g (85%) of the titled compound as yellow brown solids.

後処理

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationthe filtrate was concentrated to dryness

出典と根拠

ORDレコード
ord-199a725cd4544470a39cc7aedc2f92ec
出典データセット
uspto-grants-2001_10
特許番号
US06310079B1

関連ノート

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