Methyl iodide → HCID 178422144、化合物

HRID 382621ノート

反応式

HRID 382621 の反応式
[OH:1][C@@H:2]([C@H:4]1[C:33](=[O:34])[N:6]2[C:7]([C:20]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)=[O:21])=[C:8]([C:11]3[S:15][C:14]4=[CH:16][N:17]=[CH:18][N:13]4[C:12]=3[CH3:19])[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[I:35][CH3:36]>ClCCl>[I-:35].[CH3:19][C:12]1[N+:13]2[C:14](=[CH:16][N:17]([CH3:36])[CH:18]=2)[S:15][C:11]=1[C:8]1[C@H:9]([CH3:10])[C@@H:5]2[C@@H:4]([C@H:2]([OH:1])[CH3:3])[C:33](=[O:34])[N:6]2[C:7]=1[C:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][C:27]([N+:30]([O-:32])=[O:31])=[CH:28][CH:29]=1)=[O:21]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 120700444-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(3-methylimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate

生成物 1

HCID 178422144HCID 178422144、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 73.6 mg of 4-nitrobenzyl (1S,5R, 6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(3-methylimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate in 0.5 ml of dry dichloromethane was added 0.95 ml of iodomethane, and the mixture was stirred under the atmosphere of argon in the darkness at room temperature for 18 hours. Unreacted reagent was removed under reduced pressure to give 89.1 mg of 4-nitrobenzyl (1S,5R,6S)-2-(3,6-dimethylimidazo[5,1-b]thiazolium-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate iodide.

後処理

  1. customwas removed under reduced pressure

出典と根拠

ORDレコード
ord-ccfb4c2ea0a040f58e7cca3712df7a7d
出典データセット
uspto-grants-2001_10
特許番号
US06310056B1

反応ノート

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