Phenylacetic Acid → 2,5-Dimethyl-1-(phenylacetyl)-piperazine

HRID 38272

反応式

HRID 38272 の反応式
C(N(C(C)C)CC)(C)C.[CH3:10][C@H:11]1[CH2:16][NH:15][C@H:14]([CH3:17])[CH2:13][NH:12]1.[C:18]1([CH2:24][C:25](O)=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C.O>[CH3:10][CH:11]1[CH2:16][NH:15][CH:14]([CH3:17])[CH2:13][N:12]1[C:25](=[O:26])[CH2:24][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

7

反応物 4

HCID 999Phenylacetic AcidHCID 81531DiisopropylethylamineHCID 2206722,5-Dimethylpiperazine, trans-HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

生成物 1

HCID 649793942,5-Dimethyl-1-(phenylacetyl)-piperazine収率 178.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Diisopropylethylamine (0.38 ml) was added to a solution of trans-2,5-dimethyl-piperazine (1.50 g), phenyl acetic acid (0.59 g) and HATU (1.55 g) in DMF (10 ml). The reaction mixture was stirred overnight at ambient temperature. The solution was diluted with water, then extracted with ethyl acetate. The organic extracts were dried (MgSO4) then concentrated in vacuo to give the sub-title compound (1.8 g).

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. concentrationthen concentrated in vacuo

出典と根拠

ORDレコード
ord-715e1f13ccc9473e8841e52835088166
出典データセット
uspto-grants-2013_09
特許番号
US08524715B2

関連ノート

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