Hydrochloric Acid → Cyanomethyl-8-hydroxy-7-quinolinecarboxamide

HRID 382895ノート

反応式

HRID 382895 の反応式
[OH:1][C:2]1[C:3]([C:12]([OH:14])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[NH2:15][CH2:16][C:17]#N.Cl.CC[N:22]=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C)C=O.O.C(N(CC)CC)C>[C:16]([CH2:17][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([OH:1])[C:3]([C:12]([NH2:22])=[O:14])=[CH:4][CH:5]=2)[N:10]=1)#[N:15]

参加物

9

反応物 5

HCID 313Hydrochloric AcidHCID 10901AminoacetonitrileHCID 757711-HydroxybenzotriazoleHCID 2313638-Hydroxyquinoline-7-carboxylic AcidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

生成物 1

HCID 86757553Cyanomethyl-8-hydroxy-7-quinolinecarboxamide

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8471Triethylamine溶媒

実験手順

8-hydroxyquinoline-7-carboxylic acid (0.51 g), aminoacetonitrile.HCl (0.27 g), and triethylamine (0.38 mL) are dissolved in 10 mL dimethylformamide. EDC.HCl (0.54 g) and HOBt.H2O (0.38 g) are added and the reaction is stirred at room temperature for 2 days. The reaction is poured into 50 mL ice/H2O and stirred.

後処理

  1. stirringstirred

出典と根拠

ORDレコード
ord-a3ecd77c8a594a2393fb04309cc1f8e3
出典データセット
uspto-grants-2001_10
特許番号
US06310211B1

反応ノート

読み込み中…