1,1-Dimethylethyl 4-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]-1-piperazinecarboxylate → 1-[[2-Methoxy-5-(1-methylethyl)phenyl]methyl]-piperazine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:11])[CH3:10])=[CH:5][C:4]=1[CH2:12][N:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1>C(O)(C(F)(F)F)=O.ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:11])[CH3:10])=[CH:5][C:4]=1[CH2:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1参加物
4
実験手順
A solution of the product from step (a) (1.98 g) in TFA (4 ml) and dichloromethane (2 ml) was stirred for 2 h. The solvent was removed in vacuo and the residue azeotroped with toluene. Aq. potassium carbonate was added and the mixture was extracted with dichloromethane. The organic extracts were dried (MgSO4) and evaporated in vacuo to give the sub-title compound (1.79 g).