1-Bromo-3-chloropropane → 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride

HRID 3830

反応式

HRID 3830 の反応式
[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:18][CH2:19][CH2:20][Cl:21]>CS(C)=O>[ClH:21].[ClH:21].[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([CH2:18][CH2:19][CH2:20][Cl:21])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 7965631-(4-Fluorobenzyl)piperazine

生成物 1

HCID 201531681-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride収率 179.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The procedure described in Example 1(a) was followed, using 32.8 g of 1-(4-fluorobenzyl)piperazine, 30.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 27.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 35.2 g (61% of theory) of 1-(4-fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride as a white crystalline solid.

出典と根拠

ORDレコード
ord-734f4d7e69b04aab8269e26db78ea339
出典データセット
uspto-grants-1988_02
特許番号
US04722926

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